Unconventional CD147-dependent platelet activation elicited by SARS-CoV-2 in COVID-19.

ABSTRACT:

Background

Platelet activation and thrombotic events characterizes COVID-19.

Objectives

To characterize platelet activation and determine if SARS-CoV-2 induces platelet activation.

Patients/methods

We investigated platelet activation in 119 COVID-19 patients at admission in a university hospital in Milan, Italy, between March 18 and May 5, 2020. Sixty-nine subjects (36 healthy donors, 26 patients with coronary artery disease, coronary artery disease, and seven patients with sepsis) served as controls.

Results

COVID-19 patients had activated platelets, as assessed by the expression and distribution of HMGB1 and von Willebrand factor, and by the accumulation of platelet-derived (plt) extracellular vesicles (EVs) and HMGB1⁺ plt-EVs in the plasma. P-sele

SUBMITTER: Maugeri N 

PROVIDER: S-EPMC8646617 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature