Antiviral drugs suppress infection of 2019-nCoV spike pseudotyped virus by interacting with ACE2 protein.

ABSTRACT: The outbreak of coronavirus disease 2019 (COVID-19) has induced a large number of deaths worldwide. Angiotensin-converting enzyme 2 (ACE2) is the entry receptor for the 2019 novel coronavirus (2019-nCoV) to infect the host cells. Therefore, ACE2 may be an important target for the prevention and treatment of COVID-19. The aim of this study was to investigate the inhibition effect of valaciclovir hydrochloride (VACV), zidovudine (ZDV), saquinavir (SQV), and efavirenz (EFV) on 2019-nCoV infection. The results of molecule docking and surface plasmon resonance showed that VACV, ZDV, SQV, and EFV could bind to ACE2 protein, with the K_D value of (4.33 ± 0.09) e^-8 , (6.29 ± 1.12) e^-6 , (2.37 ± 0.59) e^-5 , and (4.85 ± 1.57) e^-5 M, respectively.

SUBMITTER: Wang J 

PROVIDER: S-EPMC8646714 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature