Identification and Construction of a Predictive Immune-Related lncRNA Signature Model for Melanoma.

ABSTRACT:

Objective

The occurrence and development mechanisms of melanoma are related to immunity and lncRNAs. Therefore, it is necessary to systematically explore immune-related lncRNA profiles to help improve the prognosis of melanoma.

Methods

We integrated immune-related lncRNAs and the basic clinical information of melanoma patients in the TCGA dataset. Immune-associated lncRNAs were selected by differential expression screening and enriched for analysis. After univariate and multivariate Cox regression analyses, a new prognostic indicator based on immune-associated lncRNAs was established.

Results

Overall, differentially expressed immune-related lncRNAs were significantly associated with clinical outcomes in patients with melanoma. A prognostic model was then established b

SUBMITTER: Li FW 

PROVIDER: S-EPMC8647169 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature