Multiple catechols in human plasma after drinking caffeinated or decaffeinated coffee.

ABSTRACT:

Background

Coffee is one of the most frequently consumed beverages worldwide. Research on effects of coffee drinking has focused on caffeine; however, coffee contains myriad biochemicals that are chemically unrelated to caffeine, including 3,4-dihydroxyphenyl compounds (catechols) such as caffeic acid and dihydrocaffeic acid (DHCA).

Objective

This prospective within-subjects study examined effects of drinking caffeinated or decaffeinated coffee on plasma free (unconjugated) catechols measured by liquid chromatography with series electrochemical detection (LCED) after batch alumina extraction. To confirm coffee-related chromatographic peaks represented catechols, plasma was incubated with catechol-O-methyltransferase and S-adenosylmethionine before the alumina extraction; red

SUBMITTER: Goldstein DS 

PROVIDER: S-EPMC8647204 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature