The X-ray structure of juvenile hormone diol kinase from the silkworm Bombyx mori.

ABSTRACT: Insect juvenile hormones (JHs) are a family of sesquiterpenoid molecules that are secreted into the haemolymph. JHs have multiple roles in insect development, metamorphosis and sexual maturation. A number of pesticides work by chemically mimicking JHs, thus preventing insects from developing and reproducing normally. The haemolymph levels of JH are governed by the rates of its biosynthesis and degradation. One enzyme involved in JH catabolism is JH diol kinase (JHDK), which uses ATP (or GTP) to phosphorylate JH diol to JH diol phosphate, which can be excreted. The X-ray structure of JHDK from the silkworm Bombyx mori has been determined at a resolution of 2.0 Å with an R factor of 19.0% and an R_free of 24.8%. The structure possesses three EF-hand motifs which are occupied by cal

SUBMITTER: Guo J 

PROVIDER: S-EPMC8647211 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature