Role of IL-1β rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis.

ABSTRACT:

Objective

Oxidative stress caused by the pro-inflammatory cytokine interleukin (IL)-1β has been widely investigated for cancer risk. In this study, we focused on the role of IL-1β rs1143634 polymorphism to reveal its impact on cancer development.

Methods

Related studies with fixed inclusion criteria were selected from electronic databases to May 2021. This meta-analysis was performed with odds ratios and 95% confidence intervals. Heterogeneity, publication bias and sensitivity analyses were also conducted. Trial sequential analysis (TSA) and in-silico gene expression analysis were performed.

Results

Forty-four case-control studies involving 18,645 patients with cancer and 22,882 controls were included. We observed a significant association of this

SUBMITTER: Jafrin S 

PROVIDER: S-EPMC8647244 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature