Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography.

ABSTRACT: Pulmonary hypertension is characterized histologically by intimal and medial thickening in the small pulmonary arteries, eventually resulting in vascular "pruning." Computed tomography (CT)-based quantification of pruning is associated with clinical measures of pulmonary hypertension, but it is not established whether CT-based pruning correlates with histologic arterial remodeling. Our sample consisted of 138 patients who underwent resection for early-stage lung adenocarcinoma. From histologic sections, we identified small pulmonary arteries and measured the relative area comprising the intima and media (VWA%), with higher VWA% representing greater histologic remodeling. From pre-operative CTs, we used image analysis algorithms to calculate the small vessel volume fraction (BV5/TBV) as a C

SUBMITTER: Synn AJ 

PROVIDER: S-EPMC8647266 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature