Association of advanced age and cancer history with autoimmune disease in melanoma patients: a cross-sectional study.

ABSTRACT:

Background

Immune-related adverse events (irAEs) are a major toxicity of immune checkpoint inhibitors. Studies have reported that pre-existing autoimmunity increases the risk of irAEs, but it remains unknown which clinical factors are linked to auto-immune disorders in cancer patients. This study aimed to evaluate if the prevalence of autoimmune diseases varied by specific cancer history and advanced age.

Methods

Our cross-sectional medical record review consisted of 291,333 patients (age, ≥18 years) treated between 2000 and 2018. Patients were classified into four study groups (melanoma only, non-cutaneous solid cancer only, melanoma and non-cutaneous cancer, and no cancer history). Dependent variable was the presence of ≥1 autoimmune disorders based on 98 conditions using

SUBMITTER: Holmes AN 

PROVIDER: S-EPMC8647353 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature