Intraoperative Urinary Biomarkers and Acute Kidney Injury After Cardiac Surgery.

ABSTRACT:

Objectives

To evaluate the association of intraoperative urinary biomarker excretion during cardiac surgery and the subsequent development of acute kidney injury (AKI).

Design

Prospective, nonrandomized, observational study.

Setting

Single tertiary-level, university-affiliated hospital.

Participants

Ninety patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).

Interventions

None.

Measurements and main results

Urinary samples were collected every 30 minutes intraoperatively and then at four, 12, and 24 hours after CPB. Samples were measured for interleukin 18 (IL-18), kidney injury molecule-1 (KIM1), and creatinine concentrations. Urinary biomarker excretion (raw and indexed to creatinine) for four intraoperative and three postopera

SUBMITTER: Silverton NA 

PROVIDER: S-EPMC8647416 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature