HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients.

ABSTRACT:

Background

Data in the literature about HSV reactivation in COVID-19 patients are scarce, and the association between HSV-1 reactivation and mortality remains to be determined. Our objectives were to evaluate the impact of Herpes simplex virus (HSV) reactivation in patients with severe SARS-CoV-2 infections primarily on mortality, and secondarily on hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP) and intensive care unit-bloodstream infection (ICU-BSI).

Methods

We conducted an observational study using prospectively collected data and HSV-1 blood and respiratory samples from all critically ill COVID-19 patients in a large reference center who underwent HSV tests. Using multivariable Cox and cause-specific (cs) models, we investigated the association betw

SUBMITTER: Meyer A 

PROVIDER: S-EPMC8647503 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature