Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds.

ABSTRACT:

Background

Diabetic wound healing remains a challenge because of its susceptibility to drug-resistant bacterial infection and its persistent proinflammatory state. Switching from proinflammatory M1 macrophages (Mφs) to proregenerative M2 dominant Mφs in a timely manner accelerates wound healing by coordinating inflammatory, proliferative, and angiogenic processes.

Methods

We propose a sequential photothermal antibacterial and subsequent M2 Mφ polarization strategy based on nanofibers (NFs) consisting of polydopamine (PDA) coating on curcumin (Cur) nanocrystals to treat Methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wounds.

Results

The PDA/Cur NFs showed excellent photothermal conversion and antibacterial effects due to the PDA shell under laser i

SUBMITTER: Xu Z 

PROVIDER: S-EPMC8647563 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature