Can 2 Different Fecal Calprotectin Assays be Used Interchangeably in IBD Treatment?

ABSTRACT:

Background

Fecal calprotectin (FC) is a biomarker for inflammation in inflammatory bowel disease (IBD). Interpretation of results can be complicated because of the use of different assays to determine FC.

Goals

To assess the agreement between 2 different assays for determining FC in patients with IBD.

Methods

Samples from adults and children with IBD were tested with 2 assays: (1) EliA 2 Calprotectin and (2) EK-Cal. Samples were uniformly tested on the same day. Interassay variability was displayed in a Bland-Altman plot. The difference in categorization of the FC result (1: 0 to 250 mg/kg, 2: 250 to 500 mg/kg, 3: >500 mg/kg) was assessed with the linear weighted κ for adults and children separately.

Results

A total of 171 patients [mean age: 33 (range: 7 to 81

SUBMITTER: van Wassenaer EA 

PROVIDER: S-EPMC8647699 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature