The casein kinase MoYck1 regulates development, autophagy, and virulence in the rice blast fungus.

ABSTRACT: Casein kinases are serine/threonine protein kinases that are evolutionarily conserved in yeast and humans and are involved in a range of important cellular processes. However, the biological functions of casein kinases in the fungus Magnaporthe oryzae, the causal agent of destructive rice blast disease, are not characterized. Here, two casein kinases, MoYCK1 and MoHRR25, were identified and targeted for replacement, but only MoYCK1 was further characterized due to the possible nonviability of the MoHRR25 deletion mutant. Disruption of MoYCK1 caused pleiotropic defects in growth, conidiation, conidial germination, and appressorium formation and penetration, therefore resulting in reduced virulence in rice seedlings and barley leaves. Notably, the

SUBMITTER: Shi HB 

PROVIDER: S-EPMC8647852 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature