Inflammatory bowel disease induces inflammatory and pre-neoplastic changes in the prostate.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) has been implicated as a risk factor for prostate cancer, however, the mechanism of how IBD leads to prostate tumorigenesis is not known. Here, we investigated whether chronic intestinal inflammation leads to pro-inflammatory changes associated with tumorigenesis in the prostate.

Methods

Using clinical samples of men with IBD who underwent prostatectomy, we analyzed whether prostate tumors had differences in lymphocyte infiltrate compared to non-IBD controls. In a mouse model of chemically-induced intestinal inflammation, we investigated whether chronic intestinal inflammation could be transferred to the wild-type mouse prostate. In addition, mouse prostates were evaluated for activation of pro-oncogenic signaling and genomic insta

SUBMITTER: Desai AS 

PROVIDER: S-EPMC8647933 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature