The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment.

ABSTRACT:

Background

Alcohol use disorder (AUD)-induced disruption of oral microbiota can lead to poor oral health; there have been no studies published examining the longitudinal effects of alcohol use cessation on the oral microbiome.

Aim

To investigate the oral microbiome during alcohol cessation during inpatient treatment for AUD.

Methods

Up to 10 oral tongue brushings were collected from 22 AUD patients during inpatient treatment at the National Institutes of Health. Alcohol use history, smoking, and periodontal disease status were measured. Oral microbiome samples were sequenced using 16S rRNA gene sequencing.

Results

Alpha diversity decreased linearly during treatment across the entire cohort (P = 0.002). Alcohol preference was associated with change

SUBMITTER: Barb JJ 

PROVIDER: S-EPMC8648028 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature