Examining the impact of neuroimmune dysregulation on social behavior of male and female juvenile rats.

ABSTRACT: Many individuals diagnosed with neuropsychiatric disorders, such as autism, attention-deficit/hyperactivity disorder, schizophrenia, and social anxiety disorder, all share a common dimension of aberrant social behavior. Epidemiological data indicate that adverse environmental factors contribute to the risk for neurodevelopmental disorders, including those associated with aberrant social behavior. Early-life exposure to infectious pathogens is one of those adverse environmental factors, suggesting that activation of the immune system during early development may contribute to disease pathology associated with altered social behavior. In the current project, we examined the impact of neonatal infection, with or without juvenile immune activation, on the expression of juvenile social behavior

SUBMITTER: Turano A 

PROVIDER: S-EPMC8648073 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature