Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults.

ABSTRACT:

Purpose

Low serum amylase activity and copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) are reportedly associated with obesity and abnormal glucose metabolism; however, this association remains controversial. We aimed to clarify the relationship between serum amylase activity and the CNV of AMY1/2A/2B with the occurrence of metabolic syndrome (MetS) in Chinese adults.

Patients and methods

Anthropometry, metabolic risk factors, and serum amylase activity were assessed in 560 subjects (260 MetS patients; 300 healthy controls). AMY1/2A/2B CNs were evaluated using the highly sensitive droplet digital PCR.

Results

The serum total, pancreatic, and salivary amylase activity, but not the AMY1/2A/2B CNs, was significantly lower i

SUBMITTER: Zhan F 

PROVIDER: S-EPMC8648087 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature