The Association of Waist Circumference and the Risk of Deep Vein Thrombosis.

ABSTRACT:

Objective

In this study, we aimed to use a two sample Mendelian randomization (MR) method to identify a potentially causality between waist circumference and the risk of deep vein thrombosis (DVT).

Methods

With a two-sample MR approach, we analyzed the summary data. The main analysis was performed by using the summary genetic data from two large consortium cohorts. Three MR approaches were used to explore MR estimates of waist circumference for DVT (inverse-variance weighted [IVW] approach, weighted median method and MR-Egger method). A total of 224 single nucleotide polymorphisms (SNPs) were identified associated with the level of waist circumference at statistical significance (P < 5*10^-8; linkage disequilibrium r² < 0.1).

Results

The result of

SUBMITTER: Lin C 

PROVIDER: S-EPMC8648090 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature