Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge.

ABSTRACT: Airway epithelial barrier dysfunction is increasingly recognized as a key feature of asthma and other lung diseases. Respiratory viruses are responsible for a large fraction of asthma exacerbations, and are particularly potent at disrupting epithelial barrier function through pattern recognition receptor engagement leading to tight junction dysfunction. Although different mechanisms of barrier dysfunction have been described, relatively little is known about whether barrier integrity can be promoted to limit disease. Here, we tested three classes of drugs commonly prescribed to treat asthma for their ability to promote barrier function using a cell culture model of virus-induced airway epithelial barrier disruption. Specifically, we studied the corticosteroid budesonide, the long acting be

SUBMITTER: Rimmer C 

PROVIDER: S-EPMC8648122 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature