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Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T ₁-T ₂ dual-mode magnetic resonance imaging probes.

ABSTRACT: The T ₁-T ₂ dual-mode probes for magnetic resonance imaging (MRI) can non-invasively acquire comprehensive information of different tissues or generate self-complementary information of the same tissue at the same time, making MRI a more flexible imaging modality for complicated applications. In this work, three Gadolinium-diethylene-triaminepentaaceticacid (Gd-DTPA) complex conjugated superparamagnetic iron oxide (SPIO) nanoparticles with different Gd/Fe molar ratio (0.94, 1.28 and 1.67) were prepared as T ₁-T ₂ dual-mode MRI probes, named as SPIO@PEG-GdDTPA0.94, SPIO@PEG-GdDTPA1.28 and SPIO@PEG-GdDTPA1.67, respectively. All SPIO@PEG-GdDTPA nanocomposites with 8 nm spherical SPIO nanocrystals showed good Gd³⁺

SUBMITTER: Yang L

PROVIDER: S-EPMC8648151 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Dataset Information

Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T ₁-T ₂ dual-mode magnetic resonance imaging probes.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T 1-T 2 dual-mode magnetic resonance imaging probes.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T ₁-T ₂ dual-mode magnetic resonance imaging probes.