Iterative reconstruction incorporating background correction improves quantification of [¹⁸F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

ABSTRACT:

Background

A confounding issue in [¹⁸F]-NaF PET/CT imaging of abdominal aortic aneurysms (AAA) is the spill in contamination from the bone into the aneurysm. This study investigates and corrects for this spill in contamination using the background correction (BC) technique without the need to manually exclude the part of the AAA region close to the bone.

Methods

Seventy-two (72) datasets of patients with AAA were reconstructed with the standard ordered subset expectation maximization (OSEM) algorithm incorporating point spread function (PSF) modelling. The spill in effect in the aneurysm was investigated using two target regions of interest (ROIs): one covering the entire aneurysm (AAA), and the other covering the aneurysm but excluding the part close to the bone

SUBMITTER: Akerele MI 

PROVIDER: S-EPMC8648624 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature