Drug combination screening as a translational approach toward an improved drug therapy for chordoma.

ABSTRACT:

Purpose

Drug screening programmes have revealed epidermal growth factor receptor inhibitors (EGFR_is) as promising therapeutics for chordoma, an orphan malignant bone tumour, in the absence of a known genetic driver. Concurrently, the irreversible EGFR_i afatinib (Giotrif®) is being evaluated in a multicentric Phase II trial. As tyrosine kinase inhibitor (TKI) monotherapies are invariably followed by resistance, we aimed to evaluate potential therapeutic combinations with EGFR_is.

Methods

We screened 133 clinically approved anticancer drugs as single agents and in combination with two EGFR_is (afatinib and erlotinib) in the clival chordoma cell line UM-Chor1. Synergistic combinations were analysed in a 7 × 7 matrix format. The most pro

SUBMITTER: Scheipl S 

PROVIDER: S-EPMC8648636 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature