Uniformity of cardiac ¹²³I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia.

ABSTRACT:

Introduction

Some studies report that assessing regional ¹²³I-cardiac MIBG uptake can aid in the diagnosis of Lewy body disease, but others report heterogeneity in healthy controls. We aimed to evaluate regional cardiac MIBG uptake patterns in healthy older adults and patients with dementia.

Methods

31 older adults with normal cognition, 15 Alzheimer's disease (AD), and 17 Dementia with Lewy bodies (DLB) patients were recruited. 5 individuals had previous myocardial infarction. Participants with sufficient cardiac uptake for regional SPECT analysis (29/31 controls, 15/15 AD, 5/17 DLB) had relative uptake pattern recorded. Controls were assessed for risk of future cardiovascular events using QRISK2, a validated online tool.

Results

In controls uptake was red

SUBMITTER: Roberts G 

PROVIDER: S-EPMC8648658 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature