Vascular uptake on ¹⁸F-sodium fluoride positron emission tomography: precursor of vascular calcification?

ABSTRACT:

Background

Microcalcifications cannot be identified with the present resolution of CT; however, ¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography (PET) imaging has been proposed for non-invasive identification of microcalcification. The primary objective of this study was to assess whether ¹⁸F-NaF activity can assess the presence and predict the progression of CT detectable vascular calcification.

Methods and results

The data of two longitudinal studies in which patients received a ¹⁸F-NaF PET-CT at baseline and after 6 months or 1-year follow-up were used. The target to background ratio (TBR) was measured on PET at baseline and CT calcification was quantified in the femoral arteries at baseline and follow-up. 128 patients

SUBMITTER: den Harder AM 

PROVIDER: S-EPMC8648691 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature