Decomposition of cell activities revealing the role of the cell cycle in driving biofunctional heterogeneity.

ABSTRACT: Heterogeneity of cell phenotypes remains a barrier in progressing cell research and a challenge in conquering cancer-related drug resistance. Cell morphology, the most direct property of cell phenotype, evolves along the progression of the cell cycle; meanwhile, cell motility, the dynamic property of cell phenotype, also alters over the cell cycle. However, a quantifiable research understanding the relationship between the cell cycle and cell migration is missing. Herein, we coordinate the migratory behaviours of NIH 3T3 fibroblasts to their corresponding phases of the cell cycle, the G1, the S, and the G2 phases, and explain the relationship through the spatiotemporal arrangements between the Rho GTPases' signals and cyclin-dependent kinase inhibitors, p21^Cip1, and p27^Kip1

SUBMITTER: Lan T 

PROVIDER: S-EPMC8648726 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature