Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers.

ABSTRACT: The tumor suppressor gene adenomatous polyposis coli (APC) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development. Recent studies have found that early-onset CRC exhibits an increased proportion of tumors lacking an APC mutation. We set out to identify mechanisms underlying APC mutation-negative (APC^mut-) CRCs. We analyzed data from The Cancer Genome Atlas to compare clinical phenotypes, somatic mutations, copy number variations, gene fusions, RNA expression, and DNA methylation profiles between APC^mut- and APC mutation-positive (APC^mut+) microsatellite stable CRCs. Transcriptionally, APC^mut- CRCs clustered into two appro

SUBMITTER: Grant A 

PROVIDER: S-EPMC8648784 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature