Exploring the genetic correlation between obesity-related traits and regional brain volumes: Evidence from UK Biobank cohort.

ABSTRACT:

Objective

To determine whether there is a correlation between obesity-related variants and regional brain volumes.

Methods

Based on a mixed linear model (MLM), we analyzed the association between 1,498 obesity-related SNPs in the GWAS Catalog and 164 regional brain volumes from 29,420 participants (discovery cohort N = 19,997, validation cohort N = 9,423) in UK Biobank. The statistically significant brain regions in association analysis were classified into 6 major neural networks (dopamine (DA) motive system, central autonomic network (CAN), cognitive emotion regulation, visual object recognition network, auditory object recognition network, and sensorimotor system). We summarized the association between obesity-related variants (metabolically healthy obesity variants, meta

SUBMITTER: Pan X 

PROVIDER: S-EPMC8648807 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature