Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.

ABSTRACT: Intrinsically-photosensitive retinal ganglion cells (ipRGCs) are non-rod/non-cone retinal photoreceptors expressing the visual pigment, melanopsin, to detect ambient irradiance for various non-image-forming visual functions. The M1-subtype, amongst the best studied, mediates primarily circadian photoentrainment and pupillary light reflex. Their intrinsic light responses are more prolonged than those of rods and cones even at the single-photon level, in accordance with the typically slower time course of non-image-forming vision. The short (OPN4S) and long (OPN4L) alternatively-spliced forms of melanopsin proteins are both present in M1-ipRGCs, but their functional difference is unclear. We have examined this point by genetically removing the Opn4 gene (Opn4^-/-) in mouse and re-e

SUBMITTER: Sheng Y 

PROVIDER: S-EPMC8648817 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature