Optimization in the expression of ASFV proteins for the development of subunit vaccines using poxviruses as delivery vectors.

ABSTRACT: African swine fever virus (ASFV) causes a highly contagious hemorrhagic disease that affects domestic pig and Eurasian wild boar populations. To date, no safe and efficacious treatment or vaccine against ASF is available. Nevertheless, there are several reports of protection elicited by experimental vaccines based on live attenuated ASFV and some levels of protection and reduced viremia in other approaches such as DNA, adenovirus, baculovirus, and vaccinia-based vaccines. Current ASF subunit vaccine research focuses mainly on delivering protective antigens and antigen discovery within the ASFV genome. However, due to the complex nature of ASFV, expression vectors need to be optimized to improve their immunogenicity. Therefore, in the present study, we constructed several recombinant MVA ve

SUBMITTER: Lopera-Madrid J 

PROVIDER: S-EPMC8648923 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature