Urinary Proadrenomedullin and Disease Severity in Children With Suspected Community-acquired Pneumonia.

ABSTRACT:

Background

Plasma proadrenomedullin (proADM) is a promising biomarker to predict disease severity in community-acquired pneumonia (CAP). Urinary biomarkers offer advantages over blood, including ease of collection. We evaluated the association between urinary proADM and disease severity in pediatric CAP.

Methods

We performed a prospective cohort study of children 3 months to 18 years with CAP. Urinary proADM/creatinine (Cr) was calculated. Disease severity was defined as: mild (discharged home), mild-moderate (hospitalized but not moderate-severe or severe), moderate-severe (eg, hospitalized with supplemental oxygen and complicated pneumonia) and severe (eg, vasopressors and invasive ventilation). Outcomes were examined using logistic regression within the cohort with suspec

SUBMITTER: Florin TA 

PROVIDER: S-EPMC8648967 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature