Urine creatinine concentration and clinical outcomes in older adults: The Cardiovascular Health Study.

ABSTRACT:

Purpose

Loss of muscle mass and strength are associated with long-term adverse health outcomes in older adults. Urine creatinine concentrations (Ucr; mg/dl) are a measure of muscle tissue mass and turnover. This study assessed the associations of a spot Ucr level with muscle mass and with risk of hospitalization, mortality, and diabetes mellitus in older adults.

Methods

We examined 3424 participants from the Cardiovascular Health Study who provided spot urine samples in 1996-1997 and who were followed through June 2015. All participants underwent baseline measurement of grip strength. In a sub-cohort, 1331 participants underwent dual energy X-ray absorptiometry (DEXA) scans, from which lean muscle mass was derived. Participants were followed for a median of 10 years for hosp

SUBMITTER: Barzilay JI 

PROVIDER: S-EPMC8648977 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature