Multimorbidity networks associated with frailty among middle-aged and older people with HIV.

ABSTRACT:

Objective

People with HIV (PWH) have increased prevalence of multimorbidity and frailty at younger ages compared with the general population. This study investigated individual and combinatorial effects of neuropsychiatric and medical comorbidities as predictors of frailty in PWH.

Design

Analysis of data from the National NeuroAIDS Tissue Consortium, a longitudinal observational cohort.

Methods

Five hundred and twenty-four PWH over age 40 years were classified using Fried's Frailty criteria. Twelve comorbidities were documented from longitudinal data and associations between individual and co-occurring comorbidities with frailty were assessed using weighted network and logistic regression analyses.

Results

At frailty assessment between 2015 and 2020, median age

SUBMITTER: Lorenz DR 

PROVIDER: S-EPMC8649075 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature