Relation Extraction of Protein Complexes from Dynamic Protein-Protein Interaction Network.

ABSTRACT:

Background

Dynamic protein-protein interaction networks (DPPIN) can confirm the conditional and temporal features of proteins and protein complexes. In addition, the relation of protein complexes in dynamic networks can provide useful information in understanding the dynamic functionality of PPI networks.

Objective

In this paper, an algorithm is presented to discover the temporal association rule from the dynamic PPIN dataset.

Material and methods

In this analytical study, the static protein-protein interaction network is transformed into a dynamic network using the gene expression thresholding to extract the protein complex relations. The number of presented proteins of the dynamic network is large at each time point. This number will increase for extraction of multi

SUBMITTER: Mohammadi Jenghara M 

PROVIDER: S-EPMC8649159 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature