Airway IL-1β associates with IL-5 production following dust mite allergen inhalation in humans.

ABSTRACT:

Background

Preclinical studies implicate interleukin (IL)-1β as a key mediator of asthma and have shown the efficacy of IL-1 antagonism for treatment of allergic airway inflammation; human studies in this area are lacking.

Objectives

Our aim was to study the relationship of airway IL-1β to features of acute allergen-induced asthma exacerbation in humans.

Methods

Dust mite-allergic adults with mild asthma underwent inhalation challenge with Dermatophagoides farinae. Fractional exhaled nitric oxide (FeNO), induced sputum and peripheral blood samples were obtained pre- and 24 h post-challenge. Spirometry was performed before and throughout the challenge at 10-min intervals, and allergen responsiveness was defined by a 20% fall in Forced Expiratory Volume in 1 s (FEV

SUBMITTER: Burbank AJ 

PROVIDER: S-EPMC8649318 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature