MiR-145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection.

ABSTRACT:

Background

miR-145 is closely related to vascular smooth muscle cells (VSMC) phenotype transformation; however, the regulatory mechanisms through which miR-145 regulates the VSMC phenotype transformation under mechanical stretching are unclear. In this study, we evaluated the roles of miR-145 in VSMCs subjected to mechanical stretching in aortic dissection (AD).

Methods

The expression of miR-145 in the aortic vessel wall of model animals and patients with AD was analyzed by quantitative polymerase chain reaction. miR-145-related protein-protein interaction networks and Wikipathways were used to analyze VSMC phenotypic transformation pathways regulated by miR-145. We used gain- and loss-of-function studies to evaluate the effects of miR-145 on VSMC differentiation under mecha

SUBMITTER: Qiu ZH 

PROVIDER: S-EPMC8649326 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature