Web-based transcriptome analysis determines a sixteen-gene signature and associated drugs on hearing loss patients: A bioinformatics approach.

ABSTRACT:

Background

Hearing loss is becoming more and more general. It may occur at all age and affect the language learning ability of children and trigger serious social problems.

Methods

The hearing loss differentially expressed genes (HL-DEGs) were recognized through a comparison with healthy subjects. The Gene Ontology (GO) analysis was executed by DAVID. The reactome analysis of HL-DEGs was performed by Clue-GO. Next, we used STRING, an online website, to identify crucial protein-protein interactions among HL-DEGs. Cytoscape software was employed to construct a protein-protein interaction network. MCODE, a plug-in of the Cytoscape software, was used for module analysis. Finally, we used DGIdb database to ascertain the targeted drugs for MCODE genes.

Results

Four hundred

SUBMITTER: Lei M 

PROVIDER: S-EPMC8649328 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature