The role of ferroptosis-related genes for overall survival prediction in breast cancer.

ABSTRACT:

Background

Ferroptosis is a novel iron-dependent form of cell death, which is implicated in various diseases including cancers. However, the influence of ferroptosis-related genes on the prognosis of breast cancer remains unclear.

Methods

RNA sequencing data of 1053 breast cancer tissue samples and 111 normal tissue samples from The Cancer Genome Atlas (TCGA) were analyzed. Expression levels of 259 ferroptosis-related genes were compared. Gene Ontology (GO) and the Kyoto Gene and Genomic Encyclopedia (KEGG) analyses were conducted on differentially expressed genes. Cox univariate analysis was conducted to explore the potential prognostic biomarkers of breast cancer. Infiltrating immune cell status was assessed.

Results

A total of 66 ferroptosis-related genes were diff

SUBMITTER: Jin LY 

PROVIDER: S-EPMC8649350 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature