A five-gene methylation signature predicts overall survival of patients with clear cell renal cell carcinoma.

ABSTRACT:

Background

In this study, we aimed to screen methylation signatures associated with the prognosis of patients with clear cell renal cell carcinoma (ccRCC).

Methods

Gene expression and methylation profiles of ccRCC patients were downloaded from publicly available databases, and differentially expressed genes (DEGs)-differentially methylated genes (DMGs) were obtained. Subsequently, gene set enrichment and transcription factor (TF) regulatory network analyses were performed. In addition, a prognostic model was constructed and the relationship between disease progression and immunity was analyzed.

Results

A total of 23 common DEGs-DMGs were analyzed, among which 14 DEGs-DMGs were obtained with a cutoff value of PCC < 0 and p < 0.05. The enrichment analysis showed that th

SUBMITTER: Jing X 

PROVIDER: S-EPMC8649352 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature