Thermogels containing sulfated hyaluronan as novel topical therapeutics for treatment of ocular surface inflammation.

ABSTRACT: The development of long lasting therapeutic agents is critically important for efficient treatment of chronic diseases. We herein report a rational strategy to develop a therapeutic thermogel featured with prolonged anti-inflammatory and corneal-protective effects. Specifically, a hyaluronic acid with different sulfation degrees and an amine-terminated poly(N-isopropylacrylamide) are conjugated to achieve the thermogels. In vitro studies reveal that the thermogels are highly biocompatible to statens seruminstitut rabbit cornea cells and their anti-inflammatory properties are strongly dependent on the sulfation degree. In a rabbit model of ocular inflammation, single-dose topical administration of a thermogel formulation could repair defects in corneal epithelium (∼99% thickne

SUBMITTER: Nguyen DD 

PROVIDER: S-EPMC8649391 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature