A nanosized anionic MOF with rich thiadiazole groups for controlled oral drug delivery.

ABSTRACT: Controlling the crystal size and surface chemistry of MOF materials, and understanding their multifunctional effect are of great significance for the biomedical applications of MOF systems. Herein, we designed and synthesized a new anionic MOF, ZJU-64-NSN, which features 1D channels decorated with highly polarized thiadiazole groups, and its crystal size could be systematically tuned from 200 ​μm to 300 ​nm through a green and simple approach. As a result, the optimal nanosized ZJU-64-NSN is found to enable an ultrafast loading of cationic drug procainamide (PA) (21.2 ​wt% within 1 ​min). Moreover, the undesirable chemical stability of PA@ZJU-64-NSN is greatly improved by the surface coating of polyethylene glycol (PEG) biopolymer. The final drug delivery system PEG/PA@ZJU-64-NSN is found

SUBMITTER: Jiang K 

PROVIDER: S-EPMC8649393 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature