Adaptive group sequential survival comparisons based on log-rank and pointwise test statistics.

ABSTRACT: Whereas the theory of confirmatory adaptive designs is well understood for uncensored data, implementation of adaptive designs in the context of survival trials remains challenging. Commonly used adaptive survival tests are based on the independent increments structure of the log-rank statistic. This implies some relevant limitations: On the one hand, essentially only the interim log-rank statistic may be used for design modifications (such as data-dependent sample size recalculation). Furthermore, the treatment arm allocation ratio in these classical methods is assumed to be constant throughout the trial period. Here, we propose an extension of the independent increments approach to adaptive survival tests that addresses some of these limitations. We present a confirmatory adaptive two-sa

SUBMITTER: Feld J 

PROVIDER: S-EPMC8649467 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature