Optimal allocation to treatments in a sequential multiple assignment randomized trial.

ABSTRACT: One of the main questions in the design of a trial is how many subjects should be assigned to each treatment condition. Previous research has shown that equal randomization is not necessarily the best choice. We study the optimal allocation for a novel trial design, the sequential multiple assignment randomized trial, where subjects receive a sequence of treatments across various stages. A subject's randomization probabilities to treatments in the next stage depend on whether he or she responded to treatment in the current stage. We consider a prototypical sequential multiple assignment randomized trial design with two stages. Within such a design, many pairwise comparisons of treatment sequences can be made, and a multiple-objective optimal design strategy is proposed to consider all such

SUBMITTER: Morciano A 

PROVIDER: S-EPMC8649474 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature