The unique pancreatic stellate cell gene expression signatures are associated with the progression from acute to chronic pancreatitis.

ABSTRACT: Chronic pancreatitis (CP) is characterized by irreversible fibro-inflammatory changes induced by pancreatic stellate cell (PSC). Unresolved or recurrent injury causes dysregulation of biological process following AP, which would cause CP. Here, we systematically identify genes whose expressions are unique to PSC by comparing transcriptome profiles among total pancreas, pancreatic stellate, acinar, islet and immune cells. We then identified candidate genes and correlated them with the pancreatic disease continuum by performing intersection analysis among total PSC and activated PSC genes, and genes persistently differentially expressed during acute pancreatitis (AP) recovery. Last, we examined the association between candidate genes and AP, and substantiated their potential as biomarkers in

SUBMITTER: Hu C 

PROVIDER: S-EPMC8649580 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature