Characteristics and outcomes of glomerulonephritis with membranoproliferative pattern in children.

ABSTRACT:

Background

Membranoproliferative glomerulonephritis (MPGN) is a rare histopathologic pattern of glomerular injury with limited studies in pediatric patients. Characteristics and outcomes of children with MPGN have also remained to be further explored.

Methods

We retrospectively reviewed the clinicopathological features, genetic findings, treatments and outcomes in 17 pediatric patients pathologically diagnosed with MPGN from 2007 to 2020 in the Children's National Medical Center in China.

Results

Median age at disease onset was 9.9 years (IQR, 5.6-11.9 years). Most of the patients (12/17) had nephrotic range of proteinuria, and nephritic-nephrotic syndrome was the most common clinical presentation (35.2%). Secondary causes were identified in eight patients including h

SUBMITTER: Xu L 

PROVIDER: S-EPMC8649586 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature