Global molecular alterations involving recurrence or progression of pediatric brain tumors.

ABSTRACT:

Background

We aimed to identify molecular changes in recurrent or progressive pediatric brain tumors, as compared to the corresponding initial tumors from the same patients, using genomic, transcriptomic, and proteomic data from a unique and large cohort of 55 patients and 63 recurrent or progressive tumors from the Children's Brain Tumor Tissue Consortium, representing various histologic types.

Methods

We carried out paired analyses for each gene between recurrent/progressive and initial tumor groups, using RNA-sequencing and mass spectrometry-based proteomic data. By whole-genome sequencing (WGS) analysis, we also examined somatic DNA events for a set of cancer-associated genes.

Results

Of 44 patients examined by WGS, 35 involved at least one cancer-associated gene

SUBMITTER: Chen F 

PROVIDER: S-EPMC8649620 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature