Research Criteria for the Behavioral Variant of Alzheimer Disease: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The behavioral variant of Alzheimer disease (bvAD) is characterized by early and predominant behavioral deficits caused by AD pathology. This AD phenotype is insufficiently understood and lacks standardized clinical criteria, limiting reliability and reproducibility of diagnosis and scientific reporting.

Objective

To perform a systematic review and meta-analysis of the bvAD literature and use the outcomes to propose research criteria for this syndrome.

Data sources

A systematic literature search in PubMed/MEDLINE and Web of Science databases (from inception through April 7, 2021) was performed in duplicate.

Study selection

Studies reporting on behavioral, neuropsychological, or neuroimaging features in bvAD and, when available, providing comparisons

SUBMITTER: Ossenkoppele R 

PROVIDER: S-EPMC8649917 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature