Targeting Mitochondrial Protein Expression as a Future Approach for Cancer Therapy.

ABSTRACT: Extensive metabolic remodeling is a fundamental feature of cancer cells. Although early reports attributed such remodeling to a loss of mitochondrial functions, it is now clear that mitochondria play central roles in cancer development and progression, from energy production to synthesis of macromolecules, from redox modulation to regulation of cell death. Biosynthetic pathways are also heavily affected by the metabolic rewiring, with protein synthesis dysregulation at the hearth of cellular transformation. Accumulating evidence in multiple organisms shows that the metabolic functions of mitochondria are tightly connected to protein synthesis, being assembly and activity of respiratory complexes highly dependent on de novo synthesis of their components. In turn, protein synthesis wi

SUBMITTER: Criscuolo D 

PROVIDER: S-EPMC8650000 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature