Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts.

ABSTRACT: Herein are reported ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages, including 2,4'-, 2,3'-, and 2,2'-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes. The methodology was successfully applied to the synthesis of the natural products caerulomycin A and E.

SUBMITTER: Horan AM 

PROVIDER: S-EPMC8650099 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature