Mesenchymal stem cell transplantation after acute myocardial infarction: a meta-analysis of clinical trials.

ABSTRACT:

Background

Trials investigating the role of mesenchymal stem cells (MSCs) in increasing ejection fraction (LVEF) after acute myocardial infarction (AMI) have raised some controversies. This study was conducted to find whether transplantation of MSCs after AMI can help improve myocardial performance indices or clinical outcomes.

Methods

Randomized trials which evaluated transplantation of MSCs after AMI were enrolled. The primary outcome was LVEF change. We also assessed the role of cell origin, cell number, transplantation time interval after AMI, and route of cell delivery on the primary outcome.

Results

Thirteen trials including 956 patients (468 and 488 in the intervention and control arms) were enrolled. After excluding the biased data, LVEF was significantly incr

SUBMITTER: Attar A 

PROVIDER: S-EPMC8650261 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature