Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts.

ABSTRACT: Mitochondria are entrusted with the challenging task of providing energy through the generation of ATP, the universal cellular currency, thereby being highly flexible to different acute and chronic nutrient demands of the cell. The fact that mitochondrial diseases (genetic disorders caused by mutations in the nuclear or mitochondrial genome) manifest through a remarkable clinical variation of symptoms in affected individuals underlines the far-reaching implications of mitochondrial dysfunction. The study of mitochondrial function in genetic or non-genetic diseases therefore requires a multi-angled approach. Taking into account that the liver is among the organs richest in mitochondria, it stands to reason that in the process of unravelling the pathogenesis of liver-related diseases, resear

SUBMITTER: Zhang IW 

PROVIDER: S-EPMC8650317 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature